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Atropine may cause anaphylaxis. Worsening of Ischemic Heart Disease In patients with ischemic heart disease, the total dose should be restricted to 2 to 3 mg maximum 0. Acute Glaucoma Atropine may precipitate acute glaucoma.
Pyloric Obstruction Atropine may convert partial organic pyloric stenosis into complete obstruction. Complete Urinary Retention Atropine may lead to complete urinary retention in patients with prostatic hypertrophy. Viscid Plugs Atropine may cause thickening of bronchial secretions and formation of viscid plugs in patients with chronic lung disease.
Benzyl Alcohol The preservative benzyl alcohol has been associated with serious adverse events and death in neonates. Additional symptoms may include gradual neurological deterioration, seizures, intracranial hemorrhage, hematologic abnormalities, skin breakdown, hepatic and renal failure, hypotension, bradycardia, and cardiovascular collapse.
Although normal therapeutic doses of this product deliver amounts of benzyl alcohol that are substantially lower than those reported in association with the "gasping syndrome", the minimum amount of benzyl alcohol at which toxicity may occur is not known.
Premature and low-birth weight infants may be more likely to develop toxicity. Practitioners administering this and other medications containing benzyl alcohol should consider the combined daily metabolic load of benzyl alcohol from all sources.
Adverse Reactions The following adverse reactions are described elsewhere in labeling: Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure.
Most of the side effects of Atropine are directly related to its antimuscarinic action. Dryness of the mouth, blurred vision, photophobia and tachycardia commonly occur. Anhidrosis can produce heat intolerance.
Constipation and difficulty in micturition may occur. Occasional hypersensitivity reactions have been observed, including serious skin rashes. Paralytic ileus may occur.
Exacerbation of reflux has been reported. Larger or toxic doses may produce such central effects as restlessness, tremor, fatigue, locomotor difficulties, delirium, followed by hallucinations, depression, and ultimately, medullary paralysis and death.
Large doses can also lead to circulatory collapse. In such cases, blood pressure declines and death due to respiratory failure may ensue following paralysis and coma.
Drug Interactions Mexiletine Atropine Sulfate Injection decreased the rate of mexiletine absorption without altering the relative oral bioavailability; this delay in mexiletine absorption was reversed by the combination of Atropine and intravenous metoclopramide during pretreatment for anesthesia.
There are risks to the mother and fetus associated with untreated severe or life-threatening muscarinic events see Clinical Considerations.
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Animal reproduction studies have not been conducted with Atropine Sulfate Injection. The estimated background risk of major birth defects and miscarriage for the indicated population is unknown.
All pregnancies have a background risk of birth defect, loss, or other adverse outcomes. Life-sustaining therapy for the pregnant woman should not be withheld due to potential concerns regarding the effects of Atropine on the fetus.
Data Human Data No adequate and well-controlled studies are available regarding use of Atropine in pregnant women. In a cohort study of pregnancies in the first trimester and pregnancies in the second or third trimester, Atropine use was not associated with an increased risk of congenital malformation.
In a surveillance study, newborns were exposed to Atropine during the first trimester; 18 major birth defects were observed when 16 were expected. No specific pattern of major birth defects was identified.
In another surveillance study of 50 pregnancies in the first trimester, Atropine use was not associated with an increased risk of malformations. Methodological limitations of these observational studies including the inability to control for the dosage and timing of Atropine exposure, underlying maternal disease, or concomitant maternal drug use, cannot definitively establish or exclude any drug-associated risk during pregnancy.
Lactation Risk Summary Trace amounts of Atropine have been reported in human milk after oral intake. There are no available data on Atropine levels in human milk after intravenous injection, the effects on the breastfed infant, or the effects on milk production.
The lack of clinical data during lactation precludes a clear determination of the risk of Atropine to an infant during lactation. Clinical Considerations Minimizing exposure The elimination half-life of Atropine is more than doubled in children less than 2 years of age [see Clinical Pharmacology To minimize potential infant exposure to Atropine Sulfate Injection, a woman may pump and discard her milk for 24 hours after use before resuming to breastfeed her infant.
Geriatric Use An evaluation of current literature revealed no clinical experience identifying differences in response between elderly and younger patients. In general, dose selection for an elderly patient should be cautious, usually starting at the low end of the dosing range, reflecting the greater frequency of decreased hepatic, renal, or cardiac function, and of concomitant disease or other drug therapy.
Overdosage Excessive dosing may cause palpitation, dilated pupils, difficulty in swallowing, hot dry skin, thirst, dizziness, restlessness, tremor, fatigue and ataxia. · Write abstract for dissertation 14 august essay writing well written high school essays chillingworth revenge essays, Essay on save water in marathi recipe.
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